Large Currents Generate Cardiac Ca2+ Sparks

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Large currents generate cardiac Ca2+ sparks.

Previous models of cardiac Ca2+ sparks have assumed that Ca2+ currents through the Ca2+ release units (CRUs) were approximately 1-2 pA, producing sparks with peak fluorescence ratio (F/F(0)) of approximately 2.0 and a full-width at half maximum (FWHM) of approximately 1 microm. Here, we present actual Ca2+ sparks with peak F/F(0) of >6 and a FWHM of approximately 2 microm, and a mathematical mo...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2001

ISSN: 0006-3495

DOI: 10.1016/s0006-3495(01)75997-8